Dr. Matthew P. Shupe is a board-certified hematologist and oncologist with over a decade of experience in patient care, academic leadership, and clinical research studies. His focus lies in integrating evidence-based medicine with compassionate care to improve outcomes for individuals battling cancer.
Dr. Matthew P. Shupe

About Dr. Shupe
Throughout his career, Dr. Shupe has served in both civilian and military healthcare systems, gaining a unique perspective on clinical practice and research. His roles have spanned academic instruction, cancer center leadership, and hands-on patient care—all of which contribute to his expertise as a clinical investigator.
Dr. Shupe’s commitment to oncology research includes participating in a wide range of trials that explore new therapies for breast cancer, lung cancer, and hematologic conditions. His involvement in national research initiatives reflects a dedication to improving treatment options and expanding access to clinical innovation.
Education
Dr. Shupe’s academic journey reflects his strong foundation in internal medicine and hematology/oncology, with training from highly respected institutions.
Formal Education and Medical Training
Doctor of Osteopathic Medicine (DO) – A.T. Still University, Kirksville College of Osteopathic Medicine, MO
2005 - 2009
Internal Medicine Residency – San Antonio Uniformed Services Health Education Consortium, TX
2009 - 2012
Hematology/Oncology Fellowship – San Antonio Uniformed Services Health Education Consortium, TX
2012 - 2016
TRAINING AND CERTIFICATION
Dr. Shupe has completed specialized training in research ethics and holds multiple active board certifications and medical licenses.
Research & Clinical Training
- CITI Web-Based Good Clinical Practice (GCP) and ICH Training (2022)
Licensure & Board Certifications
DO – Nebraska Osteopathic Physician & Surgeon
2010 - 2022
DO – California Osteopathic Physician & Surgeon
2018 - 2023
Board Certified in Internal Medicine – American Board of Internal Medicine
2012 - Present
Board Certified in Medical Oncology – American Board of Internal Medicine
2012 - Present
Board Certified in Hematology – American Board of Internal Medicine
2012 - Present
WORK EXPERIENCE
Dr. Shupe brings over 10 years of experience in oncology and hematology across clinical, academic, and leadership settings.