Expanded Access Program for Daraxonrasib launching soon. Eligible patient and physician referrals expected to begin next week.
Dr. Matthew Shupe
Physician Investigator

About Dr. Shupe

Throughout his career, Dr. Shupe has served in both civilian and military healthcare systems, gaining a unique perspective on clinical practice and research. His roles have spanned academic instruction, cancer center leadership, and hands-on patient care—all of which contribute to his expertise as a clinical investigator.

Dr. Shupe’s commitment to oncology research includes participating in a wide range of trials that explore new therapies for breast cancer, lung cancer, and hematologic conditions. His involvement in national research initiatives reflects a dedication to improving treatment options and expanding access to clinical innovation.

Education

Dr. Shupe’s academic journey reflects his strong foundation in internal medicine and hematology/oncology, with training from highly respected institutions. 

Formal Education and Medical Training

Doctor of Osteopathic Medicine (DO) – A.T. Still University, Kirksville College of Osteopathic Medicine, MO

2005 - 2009

Internal Medicine Residency – San Antonio Uniformed Services Health Education Consortium, TX

2009 - 2012

Hematology/Oncology Fellowship – San Antonio Uniformed Services Health Education Consortium, TX

2012 - 2016

TRAINING AND CERTIFICATION

Dr. Shupe has completed specialized training in research ethics and holds multiple active board certifications and medical licenses.

Research & Clinical Training

  • CITI Web-Based Good Clinical Practice (GCP) and ICH Training (2022)

Licensure & Board Certifications

DO – Nebraska Osteopathic Physician & Surgeon

2010 - 2022

DO – California Osteopathic Physician & Surgeon

2018 - 2023

Board Certified in Internal Medicine – American Board of Internal Medicine

2012 - Present

Board Certified in Medical Oncology – American Board of Internal Medicine

2012 - Present

Board Certified in Hematology – American Board of Internal Medicine

2012 - Present

WORK EXPERIENCE

Dr. Shupe brings over 10 years of experience in oncology and hematology across clinical, academic, and leadership settings.

Clinical & Academic Roles

Oncologist & Hematologist
Nebraska Hematology-Oncology, PC

2022 - Present

Staff Physician
Callahan Cancer Center, Great Plains Health North Platte, NE

2021–2022

Locum Tenens Physician
Great Plains Health

2017–2021

Locum Tenens Physician
Sanford Medical Hematology/Oncology Clinic Aberdeen, SD

2017–2021

Staff Physician
David Grant USAF Medical Center Travis AFB/Fairfield, CA

2016–2018

Chief
Joint Hematology/Oncology Infusion Clinic, David Grant USAF Medical Center, Travis AFB/Fairfield, CA

2018–2021

Assistant Professor in Medicine
Uniformed Services University, MD

2018–2021

Leadership, Committees & Appointments

Attending Physician
St. Elizabeth Regional Medical Center & Bryan Medical Center

2022 - Present

Chairman
Pharmacy and Therapeutics Committee, David Grant USAF Medical Center, Travis AFB/Fairfield, CA

2017–2021

Subject Matter Expert
Air Force MHS GENESIS, Defense Health Agency, Oncology Clinical Community

2018–2021

Physician Lead
Comfort Care/Palliative Care Order Set, David Grant USAF Medical Center

2016–2021

Member
American Society of Clinical Oncology

2012–Present